吴虹（教授）的个人简介
吴虹，博士，女，汉族，1957年3月出生于北京。美国加州大学洛杉矶分校分子和医学药理学系教授。美国加州大学洛杉矶分校分子遗传技术中心主任。JCCC癌症干细胞研究项目联合副主任。JCCC泌尿生殖系统肿瘤项目成员，信号转导研究及治疗项目成员，加州大学洛杉矶分校脑研究所成员。
在北大医学院取得学士学位后，留学美国。在哈佛大学取得生物化学博士学位，麻省理工学院白头研究所博士后。其在UCLA的实验室主要进行肿瘤细胞信号转导及分子机制研究。
2013年9月3日，正式接替饶毅，担任新一任北京大学生命科学学院院长。
学术研究
主要研究方向为肿瘤细胞信号转导及分子机制研究，曾以第一作者和通讯作者在Nature、Cell、Blood和PNAS等顶级学术期刊发表多篇有重要影响力的论文。 2011年被选为美国科学促进协会院士。
个人经历
1978年-1983年，在北京医学院（原北京医科大学，现北京大学医学部）学习，获得医学学士学位；
1984年-1991年，美国哈佛大学生物化学和分子药理学系，获得博士学位；
1991年-1996年，在美国Whitehead生物医学研究所做博士后；
1996年-2013年，美国加州大学洛杉矶分校（UCLA）分子生物学和医学药理学系助理教授至终身正教授。
2013年-今，现被聘任为北京大学讲席教授、北京大学生命科学学院院长。
媒体报道
9月3日上午，生命科学学院在金光生命科学大楼邓v才报告厅召开全院教职工大会，宣布北京大学关于学院新一届行政领导班子的任命决定。王恩哥校长携组织部部长郭海等一行出席会议，翟中和院士、朱作言院士、赵进东院士、朱玉贤院士等生命科学学院教职工约70人参加了会议。会议由学院党委书记柴真主持。
北京大学组织部郭海部长代表北京大学宣读了关于生命科学学院新一届行政领导班子的任命决定：院长吴虹，副院长柴真（兼）、王世强、李沉简、郭红卫；原班子成员自然免职。郭海部长还介绍了学院新一届行政领导班子的产生过程，并对新班子寄予厚望，相信他们一定会带领生命科学学院做出更好的成绩。
前任院长饶毅代表上一届领导班子感谢全院教职工在过去的六年里所给予的工作支持。他表示，生命科学联合中心将一如既往地支持学院发展，自己也将作为普通教授的一员继续为学院贡献力量。
新任院长吴虹代表新一届行政班子向出席会议的校领导和学院教职工介绍了班子成员的职责分工，并阐述了在本科生和研究生教学、科学研究和公共平台建设、学生工作、行政管理、校友联络等各方面工作的设想，以及具体的可行措施。吴虹院长认为，在未来五年的发展中，生命科学学院最重要的任务是明确定位和目标，理性认识学院面临的机遇与挑战，并扎扎实实地开展实际工作。学院的未来掌握在每一位教职工自己的手里，必须依靠学院全体同仁的共同努力去创造；作为新一届领导班子，要带领大家积极迎对挑战，把握机遇，主动出击，为学院在全国乃至世界生命科学领域前沿赢得一席之地。
王恩哥校长发表总结讲话。他首先充分肯定了饶毅教授率领的上一届行政班子所取得的成绩，高度评价并感谢他们为此所付出的努力；同时，他代表北京大学对学院新一届行政领导班子的履任表示热烈祝贺，并对吴虹院长阐述的学院发展理念表示赞同，号召学院全体教工支持新班子的工作。王恩哥校长认为，生命科学在今天的发展已经愈加体现出学科交叉的趋向，围绕生命科学和生命科学学院，相继成立了一批研究所和中心，形成了一个相互支撑的体系；学校将继续提供全力支持，努力发展具有北京大学特色的生命科学。
会后，学院新一届领导班子召开第一次党政联席会，就新学期的工作进行了讨论和安排。务实是这一届领导班子的一大特点，相信在生命科学学院积淀的优良传统和铺垫的坚实基础上，新一届班子一定会带领学院取得新的成绩！
学术论文
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.
Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.
Kurlawalla-Martinez, C. Stiles, B. Wang, Y. Devaskar, S. U. Kahn, B. B. Wu, H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
Lasky, J. and Wu, H. Notch signaling pathways, brain development and human disease. Pediatric Research 2005; in press.
Yue, Q. Groszer, M. Gil, J. S. Berk, A. J. Messing, A. Wu, H. Liu, X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005; 132(14): 3281-91.
Stanger, B. Z. Stiles, B. Lauwers, G. Y. Bardeesy, N. Mendoza, M. Wang, Y. Greenwood, A. Cheng, K. H. McLaughlin, M. Brown, D. Depinho, R. A. Wu, H. Melton, D. A. Dor, Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
Lasky J, and Wu H Notch signaling pathways, brain development and human disease.Pediatric Research 2005; in press.
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23.
Mulholland DJ, Dedhar S, Wu H and Nelson CC PTEN & GSK3?O: Key Regulators of Progression to Androgen Independent Prostate Cancer. . Oncogene 2005; in press.
Sanchez T, Thangada S, Wu MT, Kontos C, Wu D, Wu H And Hla T PTEN as an effector in the signaling of anti-migratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2005; 102: 4312-7.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.Development. 2005; 132(14): 3281-91.
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Roy-Burman, P. Wu, H. Powell, W. C. Hagenkord, J. Cohen, M. B. Genetically defined mouse models that mimic natural aspects of human prostate cancer development.Endocr Relat Cancer. 2004; 11(2): 225-54.
Sundaresan, G. Paulmurugan, R. Berger, F. Stiles, B. Nagayama, Y. Wu, H. Gambhir, S. S. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
Liu, B. Mink, S. Wong, K. A. Stein, N. Getman, C. Dempsey, P. W. Wu, H. Shuai, K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer. 2004; 11(2): 225-54.
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Wong, K. A. Tsai, P. T. Jegalian, A. Kertesz, N. Lee, R. Wu, H. Erythropoietin, biochemistry of.. Encyclopedia of hormones 2003; 561-569.
Freeman, D. J. Li, A. G. Wei, G. Li, H. H. Kertesz, N. Lesche, R. Whale, A. D. Martinez-Diaz, H. Rozengurt, N. Cardiff, R. D. Liu, X. Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.
Wang, S. Gao, J. Lei, Q. Rozengurt, N. Pritchard, C. Jiao, J. Thomas, G. V. Li, G. Roy-Burman, P. Nelson, P. S. Liu, X. Wu, H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Anzelon, A. N. Wu, H. Rickert, R. C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.
Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin, Biochemistry of.. In Encyclopedia of Hormones. 2003; 561-569..
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.Cancer Cell. 2003; 3(2): 117-30.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Li, G. Robinson, G. W. Lesche, R. Martinez-Diaz, H. Jiang, Z. Rozengurt, N. Wagner, K. U. Wu, D. C. Lane, T. F. Liu, X. Hennighausen, L. Wu, H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.Development. 2002; 129(17): 4159-70.
Lesche, R. Groszer, M. Gao, J. Wang, Y. Messing, A. Sun, H. Liu, X. Wu, H.Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis.2002; 32(2): 148-9.
Jegalian, A. G. Wu, H. Differential roles of SOCS family members in EpoR signal transduction. J Interferon Cytokine Res. 2002; 22(8): 853-60.
Stiles, B. Gilman, V. Khanzenzon, N. Lesche, R. Li, A. Qiao, R. Liu, X. Wu, H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Mol Cell Biol. 2002; 22(11): 3842-51.
Jegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.
Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.
Makita T, Hernandez-Hoyos G, Chen T, Wu H, Rothenberg E and Sucov H A Developmental Transition in Definitive Erythropoiesis Controlled by Competitive Regulation of Erythropoietin Expression by Retinoid Acid Receptor and HNF4.. Gene & Devel.. 2001; 15: 889-901.
Neshat M, Mellinghoff I, Tran C, Stiles B, Thomas G, Wu H, and Sawyers C Enhanced sensitively of PTEN-Deficient Tumors to Inhibition of FRAP/mTOR.. Proc. Natl. Acad. Sci. USA. . 2001; 98: 10314-1031.
Hisakawa H, Sugiyama D, Nishijima I, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Stimulates Primitive and Definitive Erythropoiesis in Mouse Embryo Expressing hGM-CSF Receptors but not Erythropoietin Receptors.. Blood . 2001; 98: 3618-3625.
Mamillapalli R, Gavrilova N, Mihaylova V, Tsvetkov L, Wu H, Zhang H and Sun H PTEN Regulates The Ubiquitin-Dependent Degradation Of The Cdk Inhibitor P27kip1 Through The Ubiquitin E3 Ligase Scfskp2.. Current Biology . 2001; 11: 263-267.
Wu, H. Lee, S. H. Gao, J. Liu, X. Iruela-Arispe, M. L. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16): 3597-605.
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Garvarina N, Mueller B, Liu X and Wu H PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.. Proc. Natl. Acad. Sci.. 1999; 96: 6199-6204.
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U and Pfeffer K Jak2 Deficiency Defines an Essential Developmental Checkpoint in Definitive Hematopoiesis.. Cell. 1998; 93: 397-409.
Liu, X. Wu, H. Loring, J. Hormuzdi, S. Disteche, C. M. Bornstein, P. Jaenisch, R. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Watowich, S. S. Wu, H. Socolovsky, M. Klingmuller, U. Constantinescu, S. N. Lodish, H. F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.
Wu, H. and Lodish, H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela-Arispe, M. L. Vernon, R. B. Wu, H. Jaenisch, R. Sage, E. H. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996; 207(2): 171-83.
Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.
Liu, X. Wu, H. Byrne, M. Jeffrey, J. Krane, S. Jaenisch, R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995; 130(1): 227-37.
Lodish, H. F. Hilton, D. J. Klingmuller, U. Watowich, S. S. Wu, H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.
Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.
Hasty, K. A. Wu, H. Byrne, M. Goldring, M. B. Seyer, J. M. Jaenisch, R. Krane, S. M. Mainardi, C. L. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13(3): 181-6.
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.
Barker, D. D. Wu, H. Hartung, S. Breindl, M. Jaenisch, R. Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Mol Cell Biol. 1991; 11(10): 5154-63.
Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Nature. 2006; 441(7092): 518-22.
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.Cancer Res. 2006; 66(4): 1929-39.
Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.
Wang, S. Garcia, A. J. Wu, M. Lawson, D. A. Witte, O. N. Wu, H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Tsai, P. T. Ohab, J. J. Kertesz, N. Groszer, M. Matter, C. Gao, J. Liu, X. Wu, H. Carmichael, S. T. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.
Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.J Cell Biol. 2005; 170(3): 413-27.
Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.
Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.Oncogene. 2004; 23(58): 9348-58.
Kertesz, N. Wu, J. Chen, T. H. Sucov, H. M. Wu, H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.
Stiles, B. Groszer, M. Wang, S. Jiao, J. Wu, H. PTENless means more. Dev Biol. 2004; 273(2): 175-84.
Chang, C. J. Freeman, D. J. Wu, H. PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem. 2004; 279(28): 29841-8.
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.. The Journal of biological chemistry. . 2004; 279(23): 24794-802.
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.
Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.
Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
Osawa, M. Yamaguchi, T. Nakamura, Y. Kaneko, S. Onodera, M. Sawada, K. Jegalian, A.Wu, H. Nakauchi, H. Iwama, A. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002; 100(8): 2769-77.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.
Jegalian, A. G. Acurio, A. Dranoff, G. Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7): 2603-5.
Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
Hisakawa, H. Sugiyama, D. Nishijima, I. Xu, M. J. Wu, H. Nakao, K. Watanabe, S. Katsuki, M. Asano, S. Arai, K. Nakahata, T. Tsuji, K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.
Lee, R. Kertesz, N. Joseph, S. B. Jegalian, A. Wu, H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.
Neshat, M. S. Mellinghoff, I. K. Tran, C. Stiles, B. Thomas, G. Petersen, R. Frost, P. Gibbons, J. J. Wu, H. Sawyers, C. L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.
Dubey, P. Wu, H. Reiter, R. E. Witte, O. N. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.
Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
Mamillapalli, R. Gavrilova, N. Mihaylova, V. T. Tsvetkov, L. M. Wu, H. Zhang, H. Sun, H. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.
Liliental, J. Moon, S. Y. Lesche, R. Mamillapalli, R. Li, D. Zheng, Y. Sun, H. Wu, H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.
Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605.
Sun, H. Lesche, R. Li, D. M. Liliental, J. Zhang, H. Gao, J. Gavrilova, N. Mueller, B. Liu, X. Wu, H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.
Neubauer, H. Cumano, A. Muller, M. Wu, H. Huffstadt, U. Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.
Klingmuller, U. Wu, H. Hsiao, J. G. Toker, A. Duckworth, B. C. Cantley, L. C. Lodish, H. F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.
Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A. 1997; 94(5): 1806-10.
Liu, X. Wu, H. Byrne, M. Krane, S. Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.
Krane, S. M. Byrne, M. H. Lemaitre, V. Henriet, P. Jeffrey, J. J. Witter, J. P. Liu, X. Wu, H. Jaenisch, R. Eeckhout, Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996; 271(45): 28509-15.
Wu, H. Liu, X. Jaenisch, R. Lodish, H. F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995; 83(1): 59-67.
Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.
Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.
Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.
Silverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.
